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This is discussed further below

When combined, these effects become unpredictable and more intense, increasing the risk of dangerous heart rhythm disturbances (arrhythmias), heart attacks, or strokes

Consider that: Worldwide, tobacco use causes more than 5 million deaths per year, and current trends show that it will cause more than 8 million deaths annually by 2030 ( WHO Report on the Global Tobacco Epidemic, 2009 )

Graphical presentations (histograms, boxplots, and spaghetti plots) will be used to facilitate the visualization of data and the time trend of endpoints and baseline variables

When it comes to regulating e-cigarettes, Europe, and the UK in particular, appear to be ahead of the pack